In non-hematologic cancers, DNA binding of ZNF217 to specific cis-regulatory regions correlates negatively with gene expression, suggesting its function as a transcriptional repressor through interaction with epigenetic regulators such as CoREST, CtBP, LSD1, and EZH2 [33]. The gene discussed is KDM1A; the disease is hematopoietic and lymphoid cell neoplasm.