Among the 24 cancer types, seven (including pancreatic adenocarcinoma (PAAD), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), bladder urothelial carcinoma (BLCA), glioblastoma (GBM), kidney renal papillary cell carcinoma (KIRP), and brain lower-grade glioma (LGG)] showed significantly poor survival in patients with high GJB2 signature scores (Fig. 5e). The gene discussed is GJB2; the disease is cancer.