In our cohort of preterm infants, we generally observed low levels of circulating IGF-1 compared to term infants.10 Our findings align with previous studies indicating that low gestational age and birth weight are the primary factors contributing to diminished IGF-1 levels.22,26 In this perspective, preterm infants with the lowest gestational age (e.g., extremely preterm infants, <29 weeks GA), born with or without SGA and/or after preeclampsia, may benefit most from raising circulating IGF-1 levels in the weeks after birth. The gene discussed is IGF1; the disease is preeclampsia.