Interestingly, the protein expression of ACSL4 has been reported to be induced by the infection with SARS-CoV-2 and influenza virus34, 35, which may explain an increase in PE-20:4 and PE-22:6 reported in the plasma of COVID-19 patients36 in addition to that in PE-20:4, PE-22:6, PC-20:4, and PC-22:6 in influenza studies23 in animal models including the present study. This evidence concerns the gene ACSL4 and COVID-19.