Lastly, the most significant CR-related genes with a CR-cancer score > 0.9 were TOP2A, CDK1, ADA, SFPQ, EZH2, IL6, NMU, FBXL6, HDAC2, ASS1, PML, PTGDS, TARDBP, SLC25A19, and SUV39H1 (Fig. 4A and Supplementary Table 38). The gene discussed is PTGDS; the disease is cancer.