The CR-related genes with both the highest f of alteration events and the highest CR-cancer scores (cutoff > 0.9) were DRD3, TP53, PTEN, NPS, GHRH, OPN5, ZPBP2, SOX14, AANAT, CSF2, GHRHR, NLGN1, FBXL6, HCRTR2, FBXW7, and KLF10. This evidence concerns the gene HCRTR2 and cancer.