As mentioned earlier, Alizarin red and Alcian blue staining showed that although newborn Padi2 KO mice did not show significant defects in skeletal structures compared to the control, Padi2 KO mice exhibited a CCD-like phenotype with hypomineralization of the calvarium and clavicular hypoplasia (Fig. 3A). The gene discussed is PADI2; the disease is cleidocranial dysplasia 1.