In research conducted by Dalmasso et al. in 2014, the upregulation of miRNA20a-5p was related to gut microbiota-induced senescence to colonic cancer cells through targeting SUMO Specific Peptidase 1 (SENP1) and inducing the SUMOylation of P5341. The gene discussed is SENP1; the disease is malignant colon neoplasm.