In this study, compared with that in the WT+BLM group, the expressions of LC3II/LC3I, Beclin1, and ATG7 of lung tissues in the Fcnb-/-+BLM group were downregulated, while p62 expression was upregulated, indicating that Fcn B could promote BLM-induced autophagy. Here, BECN1 is linked to Bloom syndrome.