IHC staining showed that NPM is up-regulated in inflammatory and cirrhotic tissues (Fig. 1A), and the phosphorylation of NPM protein at Ser125 was significantly up-regulated in liver parenchymal cells or non-parenchymal cells (Fig. 1B) of cirrhosis tissue, suggesting that NPM is related to human liver fibrosis progression. Here, NPM1 is linked to Hepatic fibrosis.