NPM1 and Hepatic fibrosis: Immunofluorescence (Fig. 4C) and IHC analysis (Fig. 4D, E) confirmed that NPM, α-SMA, and collagen I, which also are up-regulated by CCl4, were down-regulated by CIGB300.Correlation analysis showed that NPM was positively correlated with α-SMA and collagen I, and the phosphorylation of NPM (Ser125) was positively correlated with these liver fibrosis markers (Fig. 4F).