For example, a series of frameshift, nonsense and missense mutations in essential SV endocytosis and SV cargo clustering genes have been identified in individuals with intellectual disability, autism and epilepsy24, including the coat protein clathrin45, adaptor protein complexes46, SV cargo retrieval proteins47–49 and regulators of endocytosis such as TBC1D2450,51. This evidence concerns the gene GOLPH3 and Intellectual disability.