A recent study comparing a high-carbohydrate diet (72% versus 62% kcal with excess sucrose and dextrin) showed more modest effects on weight gain and tumor development compared with a lard-based HFD (60% kcal fat) in Elastase-CreERT2;KrasLoxP-STOP-LoxP-G12D (EK-ER) (Zhu et al, 2022). The gene discussed is MAP6; the disease is neoplasm.