LCN2 and neoplasm: To evaluate the function of Lcn2 in pancreatic tumorigenesis, the Cruz-Monserrate group knocked out murine Lcn2 (Lcn2−/−) in EK-ER mice and observed a significant reduction in HFD-driven tumor development and associated inflammation and fibrosis in the tumor microenvironment (Gomez-Chou et al, 2017).