CALCA and neoplasm: Both Lepob/ob and Leprdb/db accelerated oncogenic Kras-driven tumor progression in Pdx1-Cre;KrasLoxP-STOP-LoxP-G12D (KC) mice and enhanced tumor growth and metastasis in syngeneic transplant models (Zyromski et al, 2009; Incio et al, 2016a; Chung et al, 2020).