A more recent study demonstrated that obesity also induces stress granule formation via IGF1/PI3K/S6K1 signaling in orthotopic PDAC transplant models and that inhibition of stress granule formation at multiple nodes along this pathway impedes obesity-driven tumor growth in vivo (Fonteneau et al, 2022). This evidence concerns the gene RPS6KB1 and obesity due to melanocortin 4 receptor deficiency.