Conditional knockout of the rate-limiting enzyme in distal cholesterol biosynthesis (Nsdhl) diminished oncogenic Kras-driven tumor progression in mice, but PDACs that emerged exhibited a basal differentiation phenotype harboring an epithelial-to-mesenchymal (EMT) transcriptional program induced by an SREBP1/TGFβ autocrine signaling axis (Gabitova-Cornell et al, 2020). This evidence concerns the gene KRAS and neoplasm.