Using TCGA data, we similarly see that, independent of age, gender, smoking and pathological stage (online supplemental table S3), CD73 predicts reduced long-term progression-free survival (PFS) probability (figure 5Aii), and OS (online supplemental figure S13) as previously shown by Gao et al. 22 Interestingly, overall CD39 expression in the TCGA data confers improved long-term PFS (figure 5Aii) and OS (online supplemental figure S13) perhaps due to its high expression levels among immune cells and tumor specific CD8+ T cells. This evidence concerns the gene ENTPD1 and neoplasm.