The favorable NKG2D G allele was associated with elevated expression of NKG2D,18 and high expression of activating receptors may be of importance for NK cell effector functions and clinical outcome in leukemia.35 42 However, in our combined regression analysis, the effect on LFS in AML was clearly associated with variations in NKG2A rather than NKG2D. This evidence concerns the gene KLRC1 and acute myeloid leukemia.