Additionally, neurogenin2 (Ngn2) is an important transcription factor involved in neuronal differentiation, and in the mouse model of traumatic brain injury, it was found that astrocytes can target the formation of neuronal lineage via the overexpression of Ngn2.46Remarkably, NeuroD1 is an endogenous neural transcription factor. The gene discussed is NEUROD1; the disease is brain injury.