A recent research reported that reactive astrocyte highly Increases ABCA1 and its related protein, MEGF10, after ischemia.61Further studies have found that knockdown or knockout of ABCA1, MEGF10, or GULP1 can significantly reduce the phagocytic capacity of astrocytes and increase cerebral infarct volume, indicating that the removal of neuronal fragments via an ABCA1-MEGF10-GULP1 pathway-mediated phagocytosis of the reactive astrocyte is essential for nerve recovery. The gene discussed is GULP1; the disease is ischemia.