Wan et al. found the increased lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein 1 (LRP1) improved astroglial myelin phagocytosis, and Lcn2 ablation or Lrp1 knockdown alleviated demyelination and reversed white matter lesions, suggesting that astrocyte LCN2/LRP1 signaling is required for myelin phagocytosis and subsequent demyelination after focal cerebral ischemia.60Therefore, regulating the phagocytosis of astrocytes to restore synaptic connectivity or myelination may be a new therapeutic strategy of ischemic stroke. Here, LRP1 is linked to ischemic stroke.