SLC6A1 and developmental and epileptic encephalopathy: SLC6A1 encodes for the GABA transporter protein type 1 (GAT1), a membrane protein responsible for GABA neurotransmitter reuptake from the synaptic cleft in inhibitory synapses.1SLC6A1-related developmental and epileptic encephalopathy (DEE) is an autosomal dominant genetic disorder.