The data from RT‐qPCR and western blot delineated that the aggrandized expression of inflammatory cytokines including TNF‐α, IL‐1β, and IL‐6 in the liver tissues of NAFLD mice caused by HFD treatment were all declined due to deficiency of Asprosin (Figure 5A,B). Here, IL1B is linked to metabolic dysfunction-associated steatotic liver disease.