Following transfection of Asprosin interference plasmid, TNF‐α, IL‐1β, IL‐6, and p‐p65 expression were all diminished in AML‐12 cells challenged with PA (Figure 8A,B), which implied that Asprosin silencing might exert anti‐inflammatory activities on PA‐exposed AML‐12 cells. This evidence concerns the gene TNF and acute myeloid leukemia.