Quinic acid ameliorated ulcerative colitis through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways, which results in the reduction of colitis complications, including oxidative stress, inflammation, apoptosis, and histopathological injuries in rats. The gene discussed is NFKB1; the disease is ulcerative colitis.