In the present study, according to the results of previous studies, the expression of inflammatory cytokines (TLR4, TNF‐α, NF‐κB, INOS, IL‐6, and IL‐1β) and oxidative stress indicators (NO and MDA) were increased and, the levels of TAC and antioxidant enzymes (CAT and SOD) were significantly decreased, due to colitis induction. Here, TLR4 is linked to colitis.