By cross‐analyzing the DE genes in four GEO data sets with human transcription factors and querying the UALCAN database, we obtained E2F3 as one of the five candidate transcription factors (PAX5, LHX2, POU2F2, E2F3, and HOXC6) aberrantly expressed in NPC. This evidence concerns the gene E2F3 and nasopharyngeal carcinoma.