After confirming the transcriptional regulation of E2F3 on PRC1 and BIRC5 by ChIP and luciferase assays, we performed functional assays, with the results showing that either upregulation of PRC1 or BIRC5 restored the M2 skewing of TAMs and reduced the T cell activity, along with rescued malignant properties of NPC cells. Here, E2F3 is linked to nasopharyngeal carcinoma.