SIRT1 and type 2 diabetes mellitus: Mohamed et al. also revealed that LF inhibits Toll‐like receptor 4 (TLR4) in type 2 diabetes by promoting the activation of peroxisome proliferator‐activated receptor gamma (PPAR‐γ) and sirtuin 1 (SIRT‐1) proteins in the downstream NF‐κB signaling pathway.36