We first analyzed TFRC expression in mice heart tissue with pathological cardiac hypertrophy using the recently published single‐cell RNA‐seq data of TAC‐model mouse heart tissue (GSE120064),20 and found that five major cellular clusters, including cardiomyocytes (CM), endothelial cells (EC), fibroblasts (FB), macrophages (MP), and smooth muscle cells (SMC) distributed in the HF tissue (Figure 1A). The gene discussed is TFRC; the disease is cardiac hypertrophy.