Interestingly, immune checkpoint inhibitor therapy‐related cardiotoxicity and heart failure are related to immune‐infiltration of T lymphocytes, macrophages and neutrophils in myocardial tissues which is probably associated with activation of NLRP3‐MyD88‐chemokine pathways and increased expressions of systemic SDF‐1, cardiac DAMPs Fibronectin‐EDA, S100/Calgranulin, and galectine‐3 in cardiac tissues.13, 14, 15, 16. This evidence concerns the gene MYD88 and heart failure.