CD4 and rheumatoid arthritis: However, in Aeberli et al. study to explore the regulation of factors involved in lymphocyte trafficking in patients with RA undergoing treatment with tumor necrosis factor α (TNF‐α) inhibitors, they reported that there was a robust negative correlation between CXCR3+/CD4 T lymphocytes and DAS‐28 after 6‐weeks which appeared to be independent of C‐reactive protein (CRP).35