TNF and rheumatoid arthritis: CXCR3 pathway plays a key role in joint inflammation occurring in RA as it has been demonstrated that lipoxygenase, cyclooxygenase and TNF‐α inhibitors which serve as analeptic molecules inhibit the synthesis of CXCR3 ligands by synovial fibroblasts and alter the migration of CXCR3+ T cells.20, 21