Though NF-κB inhibition by JSH-23 was effective at repressing both LTT expression and cell survival in PETA and MKL-1 (Fig 5B and 5C), it is also toxic to MCPyV- MCC cells (S4 Fig), indicating that the effects of JSH-23 treatment are not specific to the downregulation of MCPyV EP activity. The gene discussed is NFKB1; the disease is Merkel cell skin cancer.