NR1H4 and cholestasis: On a molecular level, macrophage activation and cholestasis in mice corresponded to suppression of hepatic transcription of Farnesoid X receptor (Fxr) [10], Liver receptor homolog 1 (Lrh1), and canalicular transporters for bile salts (bile salt export pump (BSEP), multidrug resistance–associated protein 2 (MRP2], and the plant sterol transporters sterolin 1 and 2 (Abcg5/g8) [4, 9].