KIR3DL1 and neoplasm: Considering that maximum NK cell education is dependent on a high density of receptors and ligands and their binding strength [45] and that the KIR3DL1 alleles impact the strength of interaction with its HLA-Bw4 and HLA-Bw6 ligands, further studies with larger sample sizes are required to explore the influence of varying strengths of receptor-ligand interactions on NK cell anti-tumor and anti-viral activities in eBL patients.