RNA-sequencing is an important tool for discovering the internal development mechanism of the tumor.31 Similarly, the mechanism of drug action can be evaluated comprehensively and objectively by RNA-sequencing followed by differentially expression gene analysis and enrichment analysis of the cells before and after drug treatment.32 To explore the molecular mechanism of ST, RNA-sequencing and relative experiments were performed, and the results indicated ST had the potential to inhibit the keratinization pathway, especially for the member KRT6A. Here, KRT6A is linked to neoplasm.