DE-ERSs may also be involved in many pathways, including neuroactive ligand-receptor interaction, systemic lupus erythematosus, IL-17 signaling pathway, pancreatic secretion, Salivary secretion, chemical carcinogenesis, alcoholism, neutrophil extracellular trap formation, nicotine addiction, cAMP signaling pathway (Figure 3E). Here, IL17A is linked to nicotine dependence.