MAPT and Alzheimer disease: In AD both A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta $$\end{document}β oligomers and misfolded Tau oligomers are known to have a toxic effect on neurons (synaptic dysfunction, neurofibrillary tangle mediated neuron loss, and behavioral deficits), though it is still not well understood which is the precise role of each protein in the progression of the neurodegeneration.