In addition, experimental data have shown that the amyloid cascade hypothesis fails to provide a fully satisfactory description of the evolution of AD, since A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta $$\end{document}β and Tau seem to act in a synergistic fashion to cause cell death (see, e.g., Ittner and Götz 2011; Ricciarelli and Fedele 2017). This evidence concerns the gene MAPT and Alzheimer disease.