Interestingly, PD-L1 protein is significantly overexpressed in both tumor and non-tumor cells in primary nodal-EBV-TNKL compared to ENKTL, and this PD-L1 upregulation in primary nodal-EBV-TNKL may have potential therapeutic implications for anti-PD1 treatment [16]. This evidence concerns the gene TNKS2 and neoplasm.