Quantification of perivascular CD3/CD8 + T cells in the tegmentum of the brainstem (region of tau-pathology) did not differ between anti-IgLON5 disease and PSP without anti-IgLON5 antibodies, however parenchymal CD8/granzyme B + T cells were significantly more frequent in anti-IgLON5 patients (granzyme B staining available in 5 cases) compared to PSP and controls (Fig. 4a–c). The gene discussed is GZMB; the disease is supranuclear palsy, progressive, 1.