CDKN2A and cervical squamous intraepithelial neoplasia: Ki-67, another biomarker related to CIN grade,18 is used in association with p16INK4a in dual-staining cytology to detect HSIL in cytology specimens.19 Ki-67 has also been used to identify patients with CIN2 lesions that are more likely to progress to carcinoma20,21 and can predict CIN grade 3 or higher in women with a CIN2 biopsy.