CLDN11 and vibrio infectious disease: Despite our ability to detect antibody responses to the O139 OSP hexasaccharide, we were unable to detect significant increases in antibody responses to the capsule in both patients and vaccinees, perhaps suggesting altered immunologic display of the polysaccharide in its polymerized form, and perhaps underscoring that the ability of anti-OSP and anti-LPS antibodies to provide mechanistic protection against O139 cholera is yet to be determined.