Despite the importance of OSP-specific responses in mediating protection against cholera caused by V. cholerae O1 (23), little is known about OSP-specific responses in individual patients infected with V. cholerae O139 and in vaccine recipients of bivalent (O1/O139) oral killed cholera vaccine (OCV) currently included in the global stockpile of cholera vaccine and used in cholera control programs. Here, CLDN11 is linked to vibrio infectious disease.