MAPT and Alzheimer disease: The accumulation of extracellular and intracellular amyloid-beta (Aβ) peptide aggregates and neurofibrillary tangles, consisting of the hyperphosphorylated microtubule-associated protein tau, in the human brain has been hypothesized to play a central role in the neuropathology of AD, and efforts have been made to generate antibody-based therapeutics for targeting Aβ and tau aggregates [5, 24, 26, 36, 37].