In addition, the filaments derived from alpha‐synuclein, polyQ‐expanded huntingtin, and beta‐amyloid, which are associated with the neurodegenerative disorders such as Parkinson's, Huntington‘s, and Alzheimer's diseases, respectively, also trigger ER stress in neurons (Smith et al, 2005; Kim et al, 2008; Leitman et al, 2013). This evidence concerns the gene HTT and Alzheimer disease.