Importantly, LDH was dramatically increased after infection with both HSV‐1 and ‐2 as well as the two neurotropic RNA viruses, vesicular stomatitis virus and encephalomyocarditis virus (Fig 1A), and kinetics experiments showed that LDH and HMGB1 significantly accumulated in conditioned medium at 16 h post‐HSV‐2 infection (Fig 1B and C). The gene discussed is HMGB1; the disease is infection.