Although the pathobiology of atherosclerotic cardiovascular disease is generally similar between both sexes, there are unique aspects specific to women, with the coronary artery calcium scoring, for instance, predicting mortality better in women than in men.28 In a recent study20 using RNAseq, sex-stratified gene regulatory network analysis identified GAS6 and serpin G1 as potential key SMC driver genes in plaques from females compared with males. The gene discussed is GAS6; the disease is cardiovascular disorder.