CD40LG and neoplasm: Increased proliferation of peripheral blood capillaries facilitates more blood supply to tumor tissue which speeds up the tumor development18,19 The promotion of angiogenesis of tumor cells is through the cloned T lymphocytes differentiation by inhibiting the IgM and IgG production.17 The angiogenesis promoted with the help of TSGF produces high sensitivity and specificity with greater value in diagnosing malignant cells early.20,21 Thus, serum levels of TSGF can manifest the existence of cancer.