The clinical manifestations of SBS are diarrhea, steatorrhea, abdominal pain, electrolyte imbalances, dehydration, and malnutrition.1-3 The main reasons for SBS are surgical removal of intestine due to Crohn’s disease, cancer, traumatic injuries and dysfunction in blood supply to the intestine or congenital missing or damaged small intestine.1-3 This disability was compensated to some extent by secretion of endogenous trophic hormones and peptides such as glucagon-like peptide-2 (GLP-2), which regulate the growth, proliferation4-6 and maintenance of cells lining the gastrointestinal tract. The gene discussed is GCG; the disease is malnutrition.