MAPT and Alzheimer disease: The structure of a neuron is preserved by cytoskeletal proteins.7,14 The axonal micro-tubule (MT) is stabilized by tau protein, which also preserves the shape of axon.15 In AD, tau proteins are exposed to several PTMs that reduce the affinity of tau with MT and instead, they accumulate to form aggregates.15,16 On the contrary, depolymerization of microtubules and loss of axonal correlation lead to degeneration, which is a feature of shrunken brains.16Figure 1 presents a schematic illustration of the tauopathy presented.15