miR-155 through reducing the expression of molecules such as TAK1 (Transforming growth factor beta-activated kinase 1)-binding protein 2 (TAB2), Myeloid differentiation primary response 88(mYD88), and IkB kinase (IKK) which are involved in reinforcing the TLRs signaling pathways, attenuate this signaling pathway and impair NF-κB activation.33,34 As stated earlier, pro-inflammatory cytokines stimulate inflammatory pathways and induce osteoclastogenesis.35 Therefore, these cytokines may be involved in the pathogenesis of periodontal disease. Here, MYD88 is linked to periodontal disorder.