It seems that the overexpression of miR-155 which resulting from IFN-β, through targeting SOCS-1 and microphthalmia-associated transcription factor (MITF), which are two main regulators of osteoclastogenesis, inhibit differentiation of osteoclasts.36 Therefore, it seems that miR-155 is one of the miRNAs, which role in the immune interactions involved in periodontal disease and should be studied further. Here, MITF is linked to periodontal disorder.