We examined the mutations and types of variation in IFN-γ-related genes in each cancer type and discovered that uterine corpus endometrial carcinoma (UCEC) had the highest percentage (33%) of single nucleotide variations (SNVs) in STAT1, followed by skin cutaneous melanoma (SKCM), colon adenocarcinoma (COAD), stomach adenocarcinoma (STAD), rectum adenocarcinoma (READ), bladder urothelial carcinoma (BLCA), LUSC, and lung adenocarcinoma (LUAD). This evidence concerns the gene STAT1 and colon adenocarcinoma.