Interestingly, the alveolar macrophage and monocyte populations had a predominant pro-inflammatory phenotype in mAlum offspring, evidenced by their increase in TNFα production and a parallel decrease in IL-10 (Supplementary Figures 5B, C, F-G), a phenotype implicated in orchestrating and exacerbating pulmonary inflammation (15). The gene discussed is TNF; the disease is inflammatory response.