Studies concerning NSCLC have shown that increased histone Kla levels may cause downregulation of hemokinin-1 (HK-1) and pyruvate kinase M (PKM) in glycolysis, and upregulation of succinate dehydrogenase (SDHA) and isocitrate dehydrogenase 3 gamma (IDH3G) in the TCA cycle. The gene discussed is IDH3G; the disease is non-small cell lung carcinoma.