The levels of lactate, protein Kla, and macrophage migration inhibitory factor (MIF) in colon cancer cells were found to have significantly increased after PCSK9 overexpression, which inhibited the polarization of M1 macrophages and promoted the occurrence and development of colon cancer, providing a potential therapeutic method for the clinical control of colon cancer (33). The gene discussed is PCSK9; the disease is malignant colon neoplasm.