NSG-SGM3 transgenic mice with human stem cell factor(SCF), granulocyte-macrophage colony stimulating factor(GM‐CSF), and interleukin (IL)‐3 (121) promote the research of human myelopoietic hematological malignancy mouse models by increasing the production of mature myeloid cells (139) and enhancing the implantation rate of AML (129),MDS (140), and CLL (141). Here, CSF2 is linked to B-cell chronic lymphocytic leukemia.