CSF tau and p-tau levels were lower in persons who took more than 4 years to progress to AD (Figure 1C) (t-tau, Kruskal-Wallis test, H = 71.0, df = 3, p < 0.0001, n<2 years = 390, n<4 years = 55, n>4 years = 37, nCensored = 62; ≥ 4 years vs. < 2 years, p = 0.011, ≥4 years vs. < 4 years, 0.0086; p-tau, H = 79.4, df = 3, p < 0.0001, n<2 years = 390, n<4 years = 55, n>4 years = 37, nCensored = 62; ≥ 4 years vs. < 2 years, p = 0.011, ≥4 years vs. < 4 years, 0.0077; Benjamini-Hochberg-corrected p values for 6 pairwise comparisons). This evidence concerns the gene MAPT and Alzheimer disease.