Depending on the type of injury or infection, a multifaceted interplay of conserved inflammatory and regenerative pathways (e.g., EGFR, JAK-STAT, Wnt, BMP, Yki/Yap) activate ISC proliferation so that a sufficient PC (ISC/EB) pool is generated to replenish the damaged epithelium23,26–38. This evidence concerns the gene YAP1 and infection.