Our differential AS analysis revealed 0.3% of mis-spliced events in 2% of analyzed genes (Fig. 6a and Supplementary Fig. 6a), and 15 mis-spliced AS events overlapped between DM1 and ASD (OR = 3.5, P = 5.7 × 10−5, Fisher’s exact test), including ANK2 miE (Fig. 6b). This evidence concerns the gene ANK2 and myotonic dystrophy type 1.