Moreover, transmissible models of prion disease with ovine and bovine PrP have been stablished as potential platforms for bioassays and for the discovery of the mechanisms mediating the templated conversion of PrP (Thackray et al., 2012a, 2014, 2016, 2018, 2021; Bujdoso et al., 2015). This evidence concerns the gene PRNP and prion disease.