In hippocampal WNT pathway-related genes, compared with the control group, the expression levels of RSPO2, FZD5, WNT2, WNT5A, WNT10B, and β-catenin were significantly down-regulated, while AXIN2, GSK3-β, APC, and LRP5/6 were significantly up-regulated in the MS group. Here, RSPO2 is linked to myeloid sarcoma.