MAPT and Alzheimer disease: Openness also correlates with lower levels of aging-related hippocampal volume loss (81), and less Alzheimer’s disease-related tau accumulation in the entorhinal cortex in cognitively healthy individuals (82).Tautvydaite and colleagues found that in a mixed group of individuals with and without AD-positive biomarkers, premorbid openness predicted cognitive performance regardless of the individual’s cognitive level, demographics, APOEε4 status, or CSF biomarker levels.