PRKCE and cancer: Compelling evidence indicated that PKCε promotes EMT in different cancers, i.e., breast, prostate or head, and neck squamous cell carcinoma (Gandellini et al., 2009; Jain and Basu, 2014), whereas PKCε expression correlates with tumor grade and poor disease outcome (Pan et al., 2005, 2006; Aziz et al., 2007).