EGF and cancer: Interestingly, the growth factors (e.g., TGF-beta, PDGF, and EGF) are prominent inducers of EMT (Holz et al., 2011; Katsuno et al., 2013; Wu et al., 2013), whereas the BDNF/TrkB pathway proved effective modulator of EMT in different cells and cancer progression (Dudas et al., 2011; Serafim Junior et al., 2020; Moriwaki et al., 2022; Tian et al., 2023).