Interestingly, upon infection with common human pathogenic bacteria such as P. aeruginosa, S. aureus, and Enterococcus faecalis, many upregulated genes including icl-1, fmo-2, and acs-2, are regulated by NHR-49 (Dasgupta et al., 2020; Naim et al., 2021; Wani et al., 2021), revealing a role for this transcription factor in the innate immune response. Here, FMO2 is linked to infection.